Again, due to the crowded and insanitary conditions in the town there were instances of cholera. One family fell victim and all 3 had died within 3 days in 1849: Same day (17th August), at New Malton, aged 46, Elizabeth, wife of Mr. David Oxendale, after suffering from spasmodic cholera, 30 hours; on the 18th inst., at the cholera hospital, Malton, aged 2½ years, from spasmodic cholera and consecutive fever, Rebecca, daughter of the above David and Elizabeth Oxendale; and on the 19th inst., at the above hospital, aged 26, the above named David Oxendale, after suffering from diarrhoea 18 hours, and from Asiatic cholera ’ The coroner’s inquest concluded that the wife and daughter had ‘died from cholera brought on from want of sufficient food, through the neglect of David Oxendale, husband to the above’ 
An order of precautions against Cholera from Samuel Walker, Clerk to the Malton Union Committee of Health was published in the Malton Messenger in October 1854. The General Board of Health issued these warnings: 1. Apply for medicine to stop loose bowels as it may bring on Cholera. 2. Do not take any Strong Opening Medicine without medical advice. 3. Excess in alcohol is likely to be followed by Cholera. 4. Only drink boiled water that is clear and tastes well. 5. Don’t eat tainted or decayed meat, stale fish or raw vegetables and eat cooked vegetables and fruit in moderation. 6. Avoid fasting and be moderate at meals. 7. Avoid great fatigue and being heated and then chilled. 8. Avoid getting wet and remaining in wet clothes. 9. Keep your body and feet clean, dry and as warm as your means and occupation allows. 10. Clean and lime wash your rooms removing any dirt or impurities. 11. Open your windows as much as possible and remove any offensive smells with chloride, lime or zinc. 12. If you know of any dust or dirt heaps, foul drains or smells or any other nuisance in your house or neighbourhood report immediately to the Board of Guardians, Committee of Health, or to the Relieving Officers of the Union 
 York Herald, 25 August 1849.
 Yorkshire Gazette, 25 August 1849
 Malton Messenger, 5 October 1854
SMALL POX IN MALTON.-We are very sorry to have to state that this fatal disorder is now prevalent in Malton; several children have died of late in it, and some families have had, and have at this present time, several of their younger branches much afflicted with it. Under such circumstances we should hope parents will not neglect the precaution of vaccination.
York Herald, 24 November 1838
Towards the end of 1871 rumours were rife of a serious outbreak of smallpox in the town  ‘the wildest and most unfounded rumours were afloat, and to such an extent that some people gave their orders at shop doors, and positively objected to enter houses, and others coming by train refused to leave the railway station, and sent for their goods from the town.’ An outbreak had occurred, but on a much smaller than imagined scale. A boy infected by the disease, arrived by train from Scarbro’ on 18th November 1871, and died on 23rd November, being buried the next day. Around 40 cases subsequently occurred; all were traced back to the single case. By late February it was reported that due to the rumours the trade of the town had greatly suffered and ‘Returns from the medical men show that out of a population of 8,000, 210 cases have occurred, and 36 deaths’  The first quarter of 1872 recorded 31 deaths in the Malton Union from small-pox and concluded ‘The health of the town greatly improved during March, only two deaths from small-pox having occurred throughout the district’  The Board of Health meeting on 26 June 1872 ordered ‘that a sum of £24 be devoted for gratuities to the board’s inspector, and others for extra services rendered during the recent epidemic of small-pox ...’
 York Herald, 23 December 1871
 York Herald, 2 March 1872
 York Herald, 6 April 1872
 York Herald, 29 June 1872